Sebastian Proost, PhD

Sebastian Proost, PhD

Bioinformatics | Data Science

sebastian.proost@gmail.com

Languages

DutchEnglishGermanFrench

Skills

Python15 years 
Data Science12 years 
Flask6 years 
HTML & CSS12 years 
Linux12 years 
R9 years 
JavaScript5 years 
1 patent, 42 publications, 8430 citations. H-index : 30
* These authors contributed equally to this work

Means and methods to diagnose gut flora dysbiosis and inflammation. Patent: WO2022073973A1 (2022)

J. Raes, S. Proost, G. Falony, S. Vieira-Silva, N. J. Timpson, D. A. Hughes

Google PatentsFPO

Beyond the Norm: epidemiology of irritable bowel syndrome and mental health among sexual and gender-diverse young adults in a large representative cohort. Gastroenterology (2024)

E. Bootsma*, L. Jansen*, K. van Houte, R. C. Kessler, J. Tack , R. Bruffaerts, Gut-Brain Interactions – WHO – World Mental Health International College Student Initiative Working Group [W. Voorspoels, S. Proost, P. Mortier, G. Kiekens, J. Alonso, J. Raes, G. Falony, S. Vieira-Silva, L. van Oudenhove, P. Cuijpers, R. P. Auerbach]

Gastroenterology

Associations of HIV and iron status with gut microbiota composition, gut inflammation, and gut integrity in South African school-age children: A two-way factorial case-control study. Journal of Human Nutrition and Dietetics (2023)

C. Goosen*, S. Proost*, J. Baumgartner, K. Mallick, R. Y. Tito, S. L. Barnabas, M. F. Cotton, M. B. Zimmermann, J. Raes, R. Blaauw

JHND

Mood disorders in higher education in Flanders during the 2nd COVID-19 wave: Prevalence and help-seeking: Findings from the Flemish College Surveys (FLeCS). Journal of Psychiatric Research (2023)

E. Bootsma*, L. Jansen*, G. Kiekens, W. Voorpoels, P. Mortier, S. Proost, I. van de Poel, K. Jacobs, K. Demyttenaere, J. Alonso, R. C. Kessler, P. Cuijpers, R. P. Auerbach and R. Bruffaerts

Journal of Psychiatric Research

Long-term life history predicts current gut microbiome in a population-based cohort study. Nature Aging (2022)

J. Si, J. F. Vázquez-Castellanos, A. C. Gregory, L. Decommer, L. Rymenans, S. Proost, J. Centelles Lodeiro, M. Weger, M. Notdurfter, C. Leitner, P. Santer, G. Rungger, J. Willeit, P. Willeit, R. Pechlaner, F. Grabherr, S. Kiechl, H. Tilg and J. Raes

Nature Aging

High-energy level metabolism and transport revealed at the transition from close to open flowers. Plant Physiology (2022)

M. Borghi, L. Perez de Souza, T. Tohge, J. Mi, G. Melandri, S. Proost, M. Martins, S. Al-Babili, H. Bouwmeester and A. Fernie

Plant Physiology

The effect of ß-glucan prebiotic on kidney function, uremic toxins and gut microbiome in stage 3 to 5 chronic kidney disease (CKD) predialysis participants: a randomized controlled trial. Nutrients (2022)

Z. Ebrahim*, S. Proost*, R. Y. Tito, J. Raes, G. Glorieux, M. R. Moosa and R. Blaauw

MDPI

The effect of oral iron supplementation on the gut microbiota, gut inflammation, and iron status in iron-depleted South African school-age children with virally suppressed HIV and without HIV. European Journal of Nutrition (2022)

C. Goosen*, S. Proost*, R. Y. Tito, J. Baumgartner, S. L. Barnabas, M. F. Cotton, M. B. Zimmermann, J. Raes and R. Blaauw

Springer Link

Topology of the redox network during induction of photosynthesis as revealed by time-resolved proteomics in tobacco. Science Advances (2021)

D. Zimmer, C. Swart, A. Graf, S. Arrivault, M. Tillich, S. Proost, Z. Nikoloski, M. Stitt, R. Bock, T. Mühlhaus and A. Boulouis

Science Advances

Comparative transcriptomic analysis reveals conserved transcriptional programs underpinning organogenesis and reproduction in land plants. Nature Plants (2021)

I. Julca, C. Ferrari, M. Flores-Tornero, S. Proost, A.-C. Lindner, ... , J. D. Becker and M. Mutwil

PubMed

Kingdom-wide analysis of the evolution of the plant type III polyketide synthase superfamily. Plant Physiology (2021)

T. Naake, H. A. Maeda, S. Proost, T. Takayuki, A. R. Fernie

PubMed

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature (2020)

S. Vieira-Silva, G. Falony, E. Belda, T. Nielsen, J. Aron-Wisnewsky, R. Chakaroun, S. K. Forslund, K. Assmann, M. Valles-Colomer, T. T. D. Nguyen, S. Proost, ... , K. Clément and J. Raes

PubMed

A novel seed plants gene regulates oxidative stress tolerance in Arabidopsis thaliana. Cellular and Molecular Life Sciences (2019)

N. Sujeeth, N. Mehterov, S. Gupta, M. K. Qureshi, A. Fischer, S. Proost, M. A. Omidbakhshfard, T. Obata, M. Benina, N. Staykov, S. Balazadeh, D. Walther, A. R. Fernie, B. Mueller-Roeber, J. Hille, T. S. Gechev

PubMed

Appropriate thiamin pyrophosphate levels are required for acclimation to changes in photoperiod. Plant Physiology (2019)

L. Rosado-Souza, S. Proost, M. Moulin, S. Bergmann, S. Bocobza, A. Aharoni, T. B. Fitzpatrick, M. Mutwil, A. R. Fernie, T. Obata

PubMed

Kingdom-wide comparison reveals the evolution of diurnal gene expression in Archaeplastida. Nature Communications (2019)

C. Ferrari, S. Proost, M. Janowski, J. Becker, Z. Nikoloski, D. Bhattacharya, D. Price, T. Tohge, A. Bar-Even, A. Fernie, M. Stitt, M. Mutwil

PubMed

Transcriptomics of manually isolated Amborella trichopoda egg apparatus cells. Plant Reproduction (2019)

M. Flores-Tornero, S. Proost, M. Mutwil, C. P. Scutt, T. Dresselhaus, S. Sprunck

PubMed

Multi‐tissue integration of transcriptomic and specialized metabolite profiling provides tools for assessing the common bean (Phaseolus vulgaris) metabolome. The Plant Journal (2018)

L. Perez de Souza, F. Scossa, S. Proost, E. Bitocchi, R Papa, T. Tohge, A. R. Fernie

PubMed

CoNekT: an open-source framework for comparative genomic and transcriptomic network analyses. Nucleic Acids Research (2018)

S. Proost, M. Mutwil

PubMedGitHub

PhytoNet: Comparative co-expression network analyses across phytoplankton and land plants. Nucleic Acids Research (2018)

C. Ferrari, S. Proost, C. Ruprecht, M. Mutwil

PubMed

AtRsgA from Arabidopsis thaliana controls maturation of the small subunit of the chloroplast ribosome. The Plant Journal (2018)

M. Janowski, R. Zoschke, L Scharff, S. Martinez Jaime, C. Ferrari, S. Proost, N. Omranian, M. Musialak-Lange, Z. Nikoloski, A. Graf, M. A. Schottler, A. Sampathkumar, N. Vaid, M. Mutwil

PubMed

LSTrAP: efficiently combining RNA sequencing data into co-expression networks. BMC Bioinformatics (2017)

S. Proost, A. Krawczyk, M. Mutwil

PubMedGitHub

Expression atlas and comparative co-expression network analyses reveal important genes involved in the formation of lignified cell wall in Brachypodium distachyon. New Phytologist (2017)

R. Sibout, S. Proost, B. Hansen, N. Vaid, F. Giorgi, S. Ho-Yue-Kuang, F. Legée, L. Cezart, O. Bouchabké-Coussa, C. Soulhat, N. Provart, A. Pasha, P. Le Bris, E. Jamet, D. Roujol, H. Hoefte, C. Lapierre, S. Persson, M. Mutwil

PubMed

Phylogenomic analysis of gene co-expression networks reveals evolution of functional modules. The Plant Journal (2017)

C. Ruprecht, S. Proost, M. Hernandez-Coronado, C. Ortiz-Ramirez, D. Lang, S. A. Rensing, J. D. Becker, K. Vandepoele, M. Mutwil

PubMed

Beyond genomics: studying evolution with gene networks. Trends in Plant Science (2017)

C. Ruprecht, N. Vaid, S. Proost, S. Persson, M. Mutwil

PubMed

PlaNet: Comparative Co-Expression Network Analyses for Plants. Plant Genomics Databases (Book Chapter) (2017)

S. Proost, M.Mutwil

PubMed

Novel allelic variants in ACD6 cause hybrid necrosis in local collection of Arabidopsis thaliana. New Phytologist (2017)

M. Swiadek*, S. Proost*, D. Sieh, J. Yu, M. Todesco, C. Jorzig, A. E. Rodriguez Cubillos, B. Ploetner, Z. Nikoloski, E. Chae, P. Giavalisco, A. Fischer, F. Schroeder, S.-T. Kim, D. Weigel, R.A.E. Laitinen

PubMed

Tools of the trade: studying molecular networks in plants. Current Opinion in Plant Biology (2016)

S. Proost, M.Mutwil

PubMed

Growth-regulating factors (GRFs): a small transcription factor family with important functions in plant biology. Molecular Plant (2015)

M. A. Omidbakhshfard, S. Proost, U. Fujikura, B. Mueller-Roeber

PubMed

The genome sequence of the orchid Phalaenopsis equestris. Nature Genetics (2015)

J. Cai*, X. Liu*, K. Vanneste*, S. Proost*, W.-C. Tsai*, K.-W. Liu*, ..., Y. Van de Peer, and Z.-J. Liu

PubMed

PLAZA 3.0: an access point for plant comparative genomics. Nucleic Acids Research (2014)

S. Proost*, M. Van Bel*, D. Vaneechoutte, Y. Van de Peer, D. Inzé, B. Mueller-Roeber, and K. Vandepoele

PubMedLink

Reversal of senescence by N resupply to N-starved Arabidopsis thaliana: transcriptomic and metabolomic consequences. Journal of Experimental Botany (2014)

S. Balazadeh, J. Schildhauer, W. L. Araújo, S. Munné-Bosch, A. R Fernie, S. Proost, K. Humbeck, and B. Mueller-Roeber

PubMed

TRAPID: an efficient online tool for the functional and comparative analysis of de novo RNA-Seq transcriptomes. Genome Biology (2013)

M. Van Bel, S. Proost, C. Van Neste, D. Deforce, Y. Van de Peer, and K. Vandepoele

PubMedLink

FLOWERING LOCUS C in monocots and the tandem origin of angiosperm-specific MADS-box genes. Nature Communications (2013)

P. Ruelens, R. A. de Maagd, S. Proost, G. Theißen, K. Geuten, and K. Kaufmann

PubMed

Gamma paleohexaploidy in the stem lineage of core eudicots: significance for MADS-Box gene and species diversification. Molecular Biology and Evolution (2012)

D. Vekemans*, S. Proost*, K. Vanneste, H. Coenen, T. Viaene, P. Ruelens, S. Maere, Y. Van de Peer, and K. Geuten

PubMed

Dissecting plant genomes with the PLAZA comparative genomics platform. Plant Physiology (2012)

M. Van Bel*, S. Proost*, E. Wischnitzki, S. Mohavedi, C. Scheerlinck, Y. Van de Peer, and K. Vandepoele

PubMedLink

i-ADHoRe 3.0 - fast and sensitive detection of genomic homology in extremely large data sets. Nucleic Acids Research (2012)

S. Proost*, J. Fostier*, D. De Witte, B. Dhoedt, P. Demeester, Y. Van de Peer, and K. Vandepoele

PubMedGitHub

The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011)

N. D. Young, F. Debelle, G. Oldroyd, R. Geurts, S. B. Cannon, M. K. Udvardi, V. A. Benedito, K. F. X. Mayer, J. Gouzy, H. Schoof, Y. Van de Peer, S. Proost, D. R. Cook, ..., D. C. Schwartz, J. Rogers, F. Quetier, C. D. Town, and B. A. Roe

PubMed

Journey through the past: 150 million years of plant genome evolution. The Plant Journal (2011)

S. Proost, P. Pattyn, T. Gerats, and Y. Van de Peer

PubMed

A greedy, graph-based algorithm for the alignment of multiple homologous gene lists. Bioinformatics (2011)

J. Fostier*, S. Proost*, B. Dhoedt, Y. Saeys, P. Demeester, Y. Van de Peer, and K. Vandepoele

PubMedGitHub

The genome of the domesticated apple (Malus x domestica Borkh.). Nature genetics (2010)

R. Velasco, A. Zharkikh, J. Affourtit, A. Dhingra, A. Cestaro, A. Kalyanaraman, P. Fontana, S. K. Bhatnagar, M. Troggio, D. Pruss, ..., J. A. Fawcett, S. Proost, P. Rouze, L. Sterck, S. Toppo, B. Lazzari, R. P. Hellens, C. E. Durel, A. Gutin, R. E. Bumgarner, S. E. Gardiner, M. Skolnick, M. Egholm, Y. Van de Peer, F. Salamini, and R. Viola

PubMed

The flowering world: a tale of duplications. Trends in Plant Science (2009)

Y. Van de Peer, J. A. Fawcett, S. Proost, L. Sterck, and K. Vandepoele

PubMed

PLAZA: a comparative genomics resource to study gene and genome evolution in plants. The Plant Cell (2009)

S. Proost*, M. Van Bel*, L. Sterck, K. Billiau, T. Van Parys, Y. Van de Peer, and K. Vandepoele

PubMedLink

Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression. BMC Genomics (2009)

S. De Bodt, S. Proost, K. Vandepoele, P. Rouze, and Y. Van de Peer

PubMed