Sebastian Proost

Sebastian Proost

PhD

Project Manager · Bioinformatics, AI & Data Science

VIB-KULeuven Center for Microbiology · Leuven, Belgium

Python AI Machine Learning Data Science Flask HTML & CSS Linux R JavaScript
46 Publications
9,383 Citations
33 H-Index
2 Patents
2Patents
46Publications
9,383Citations
33H-Index

Development and validation of an LC-MS/MS method for the simultaneous detection of urinary inflammatory biomarkers in a Flemish birth cohort

2025

Journal of Chromatography B

F. den Ouden, A. Cseresznye, L. Engelen, E. Maris, E. De Paepe, G. Poma, S. Proost, A. Vich i Vila, L. Y. Hemeryck, R. Pero-Gascon, S. De Saeger, J. Raes, L. Vanhaecke, T. S. Nawrot, and A. Covaci

Chemical exposure in childhood: A study on organophosphate flame retardants and plasticizers in a Flemish birth cohort

2025

Environmental Research

F. den Ouden, A. Cseresznye, L. Engelen, E. Maris, S. Bosschaerts, C. Gys, P. Cleys, Y. Ait Bamai, R. Pero-Gascon, L. Y. Hemeryck, E. De Paepe, S. Proost, A. Vich Vila, J. Raes, L. Vanhaecke, M. De Boevre, S. De Saeger, T. S. Nawrot, G. Poma, and A. Covaci

Dietary convergence induces individual responses in faecal microbiome composition

2025

eGastroenterology

A. Vermeulen*, E. Bootsma*, S. Proost*, S. Vieira-Silva*, G. Kathagen*, J. F. Vázquez-Castellanos, R. Y. Tito, J. Sabino, S. Vermeire, C. Matthys, J. Raes and G. Falony

Elevated serum levels of interleukin-18 discriminate Still’s disease from other autoinflammatory conditions: results from the European ImmunAID cohort

2025

RMD Open

C. Girard-Guyonvarc’h, E. Rodriguez, Y. M. Mueller, A. Caruso, P. D. Katsikis and C. Gabay, The ImmunAID consortium [incl. S. Proost]

Means and methods to classify the gut microbiome

2025

Patent · WO2025125682

J. Raes, S. Proost, G. Falony

Beyond the Norm: epidemiology of irritable bowel syndrome and mental health among sexual and gender-diverse young adults in a large representative cohort

2024

Gastroenterology

E. Bootsma*, L. Jansen*, K. van Houte, R. C. Kessler, J. Tack , R. Bruffaerts, Gut-Brain Interactions – WHO – World Mental Health International College Student Initiative Working Group [W. Voorspoels, S. Proost, P. Mortier, G. Kiekens, J. Alonso, J. Raes, G. Falony, S. Vieira-Silva, L. van Oudenhove, P. Cuijpers, R. P. Auerbach]

Associations of HIV and iron status with gut microbiota composition, gut inflammation, and gut integrity in South African school-age children: A two-way factorial case-control study

2023

Journal of Human Nutrition and Dietetics

C. Goosen*, S. Proost*, J. Baumgartner, K. Mallick, R. Y. Tito, S. L. Barnabas, M. F. Cotton, M. B. Zimmermann, J. Raes, R. Blaauw

Mood disorders in higher education in Flanders during the 2nd COVID-19 wave: Prevalence and help-seeking: Findings from the Flemish College Surveys (FLeCS)

2023

Journal of Psychiatric Research

E. Bootsma*, L. Jansen*, G. Kiekens, W. Voorpoels, P. Mortier, S. Proost, I. van de Poel, K. Jacobs, K. Demyttenaere, J. Alonso, R. C. Kessler, P. Cuijpers, R. P. Auerbach and R. Bruffaerts

Long-term life history predicts current gut microbiome in a population-based cohort study

2022

Nature Aging

J. Si, J. F. Vázquez-Castellanos, A. C. Gregory, L. Decommer, L. Rymenans, S. Proost, J. Centelles Lodeiro, M. Weger, M. Notdurfter, C. Leitner, P. Santer, G. Rungger, J. Willeit, P. Willeit, R. Pechlaner, F. Grabherr, S. Kiechl, H. Tilg and J. Raes

High-energy level metabolism and transport revealed at the transition from close to open flowers

2022

Plant Physiology

M. Borghi, L. Perez de Souza, T. Tohge, J. Mi, G. Melandri, S. Proost, M. Martins, S. Al-Babili, H. Bouwmeester and A. Fernie

The effect of ß-glucan prebiotic on kidney function, uremic toxins and gut microbiome in stage 3 to 5 chronic kidney disease (CKD) predialysis participants: a randomized controlled trial

2022

Nutrients

Z. Ebrahim*, S. Proost*, R. Y. Tito, J. Raes, G. Glorieux, M. R. Moosa and R. Blaauw

The effect of oral iron supplementation on the gut microbiota, gut inflammation, and iron status in iron-depleted South African school-age children with virally suppressed HIV and without HIV

2022

European Journal of Nutrition

C. Goosen*, S. Proost*, R. Y. Tito, J. Baumgartner, S. L. Barnabas, M. F. Cotton, M. B. Zimmermann, J. Raes and R. Blaauw

Means and methods to diagnose gut flora dysbiosis and inflammation

2022

Patent · WO2022073973A1

J. Raes, S. Proost, G. Falony, S. Vieira-Silva, N. J. Timpson, D. A. Hughes

Topology of the redox network during induction of photosynthesis as revealed by time-resolved proteomics in tobacco

2021

Science Advances

D. Zimmer, C. Swart, A. Graf, S. Arrivault, M. Tillich, S. Proost, Z. Nikoloski, M. Stitt, R. Bock, T. Mühlhaus and A. Boulouis

Comparative transcriptomic analysis reveals conserved transcriptional programs underpinning organogenesis and reproduction in land plants

2021

Nature Plants

I. Julca, C. Ferrari, M. Flores-Tornero, S. Proost, A.-C. Lindner, ... , J. D. Becker and M. Mutwil

Kingdom-wide analysis of the evolution of the plant type III polyketide synthase superfamily

2021

Plant Physiology

T. Naake, H. A. Maeda, S. Proost, T. Takayuki, A. R. Fernie

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

2020

Nature

S. Vieira-Silva, G. Falony, E. Belda, T. Nielsen, J. Aron-Wisnewsky, R. Chakaroun, S. K. Forslund, K. Assmann, M. Valles-Colomer, T. T. D. Nguyen, S. Proost, ... , K. Clément and J. Raes

A novel seed plants gene regulates oxidative stress tolerance in Arabidopsis thaliana

2019

Cellular and Molecular Life Sciences

N. Sujeeth, N. Mehterov, S. Gupta, M. K. Qureshi, A. Fischer, S. Proost, M. A. Omidbakhshfard, T. Obata, M. Benina, N. Staykov, S. Balazadeh, D. Walther, A. R. Fernie, B. Mueller-Roeber, J. Hille, T. S. Gechev

Appropriate thiamin pyrophosphate levels are required for acclimation to changes in photoperiod

2019

Plant Physiology

L. Rosado-Souza, S. Proost, M. Moulin, S. Bergmann, S. Bocobza, A. Aharoni, T. B. Fitzpatrick, M. Mutwil, A. R. Fernie, T. Obata

Kingdom-wide comparison reveals the evolution of diurnal gene expression in Archaeplastida

2019

Nature Communications

C. Ferrari, S. Proost, M. Janowski, J. Becker, Z. Nikoloski, D. Bhattacharya, D. Price, T. Tohge, A. Bar-Even, A. Fernie, M. Stitt, M. Mutwil

Transcriptomics of manually isolated Amborella trichopoda egg apparatus cells

2019

Plant Reproduction

M. Flores-Tornero, S. Proost, M. Mutwil, C. P. Scutt, T. Dresselhaus, S. Sprunck

Multi‐tissue integration of transcriptomic and specialized metabolite profiling provides tools for assessing the common bean (Phaseolus vulgaris) metabolome

2018

The Plant Journal

L. Perez de Souza, F. Scossa, S. Proost, E. Bitocchi, R Papa, T. Tohge, A. R. Fernie

CoNekT: an open-source framework for comparative genomic and transcriptomic network analyses

2018

Nucleic Acids Research

S. Proost, M. Mutwil

PhytoNet: Comparative co-expression network analyses across phytoplankton and land plants

2018

Nucleic Acids Research

C. Ferrari, S. Proost, C. Ruprecht, M. Mutwil

AtRsgA from Arabidopsis thaliana controls maturation of the small subunit of the chloroplast ribosome

2018

The Plant Journal

M. Janowski, R. Zoschke, L Scharff, S. Martinez Jaime, C. Ferrari, S. Proost, N. Omranian, M. Musialak-Lange, Z. Nikoloski, A. Graf, M. A. Schottler, A. Sampathkumar, N. Vaid, M. Mutwil

LSTrAP: efficiently combining RNA sequencing data into co-expression networks

2017

BMC Bioinformatics

S. Proost, A. Krawczyk, M. Mutwil

Expression atlas and comparative co-expression network analyses reveal important genes involved in the formation of lignified cell wall in Brachypodium distachyon

2017

New Phytologist

R. Sibout, S. Proost, B. Hansen, N. Vaid, F. Giorgi, S. Ho-Yue-Kuang, F. Legée, L. Cezart, O. Bouchabké-Coussa, C. Soulhat, N. Provart, A. Pasha, P. Le Bris, E. Jamet, D. Roujol, H. Hoefte, C. Lapierre, S. Persson, M. Mutwil

Phylogenomic analysis of gene co-expression networks reveals evolution of functional modules

2017

The Plant Journal

C. Ruprecht, S. Proost, M. Hernandez-Coronado, C. Ortiz-Ramirez, D. Lang, S. A. Rensing, J. D. Becker, K. Vandepoele, M. Mutwil

Beyond genomics: studying evolution with gene networks

2017

Trends in Plant Science

C. Ruprecht, N. Vaid, S. Proost, S. Persson, M. Mutwil

PlaNet: Comparative Co-Expression Network Analyses for Plants

2017

Plant Genomics Databases (Book Chapter)

S. Proost, M.Mutwil

Novel allelic variants in ACD6 cause hybrid necrosis in local collection of Arabidopsis thaliana

2017

New Phytologist

M. Swiadek*, S. Proost*, D. Sieh, J. Yu, M. Todesco, C. Jorzig, A. E. Rodriguez Cubillos, B. Ploetner, Z. Nikoloski, E. Chae, P. Giavalisco, A. Fischer, F. Schroeder, S.-T. Kim, D. Weigel, R.A.E. Laitinen

Tools of the trade: studying molecular networks in plants

2016

Current Opinion in Plant Biology

S. Proost, M.Mutwil

Growth-regulating factors (GRFs): a small transcription factor family with important functions in plant biology

2015

Molecular Plant

M. A. Omidbakhshfard, S. Proost, U. Fujikura, B. Mueller-Roeber

The genome sequence of the orchid Phalaenopsis equestris

2015

Nature Genetics

J. Cai*, X. Liu*, K. Vanneste*, S. Proost*, W.-C. Tsai*, K.-W. Liu*, ..., Y. Van de Peer, and Z.-J. Liu

PLAZA 3.0: an access point for plant comparative genomics

2014

Nucleic Acids Research

S. Proost*, M. Van Bel*, D. Vaneechoutte, Y. Van de Peer, D. Inzé, B. Mueller-Roeber, and K. Vandepoele

Reversal of senescence by N resupply to N-starved Arabidopsis thaliana: transcriptomic and metabolomic consequences

2014

Journal of Experimental Botany

S. Balazadeh, J. Schildhauer, W. L. Araújo, S. Munné-Bosch, A. R Fernie, S. Proost, K. Humbeck, and B. Mueller-Roeber

TRAPID: an efficient online tool for the functional and comparative analysis of de novo RNA-Seq transcriptomes

2013

Genome Biology

M. Van Bel, S. Proost, C. Van Neste, D. Deforce, Y. Van de Peer, and K. Vandepoele

FLOWERING LOCUS C in monocots and the tandem origin of angiosperm-specific MADS-box genes

2013

Nature Communications

P. Ruelens, R. A. de Maagd, S. Proost, G. Theißen, K. Geuten, and K. Kaufmann

Gamma paleohexaploidy in the stem lineage of core eudicots: significance for MADS-Box gene and species diversification

2012

Molecular Biology and Evolution

D. Vekemans*, S. Proost*, K. Vanneste, H. Coenen, T. Viaene, P. Ruelens, S. Maere, Y. Van de Peer, and K. Geuten

Dissecting plant genomes with the PLAZA comparative genomics platform

2012

Plant Physiology

M. Van Bel*, S. Proost*, E. Wischnitzki, S. Mohavedi, C. Scheerlinck, Y. Van de Peer, and K. Vandepoele

i-ADHoRe 3.0 - fast and sensitive detection of genomic homology in extremely large data sets

2012

Nucleic Acids Research

S. Proost*, J. Fostier*, D. De Witte, B. Dhoedt, P. Demeester, Y. Van de Peer, and K. Vandepoele

The Medicago genome provides insight into the evolution of rhizobial symbioses

2011

Nature

N. D. Young, F. Debelle, G. Oldroyd, R. Geurts, S. B. Cannon, M. K. Udvardi, V. A. Benedito, K. F. X. Mayer, J. Gouzy, H. Schoof, Y. Van de Peer, S. Proost, D. R. Cook, ..., D. C. Schwartz, J. Rogers, F. Quetier, C. D. Town, and B. A. Roe

Journey through the past: 150 million years of plant genome evolution

2011

The Plant Journal

S. Proost, P. Pattyn, T. Gerats, and Y. Van de Peer

A greedy, graph-based algorithm for the alignment of multiple homologous gene lists

2011

Bioinformatics

J. Fostier*, S. Proost*, B. Dhoedt, Y. Saeys, P. Demeester, Y. Van de Peer, and K. Vandepoele

The genome of the domesticated apple (Malus x domestica Borkh.)

2010

Nature genetics

R. Velasco, A. Zharkikh, J. Affourtit, A. Dhingra, A. Cestaro, A. Kalyanaraman, P. Fontana, S. K. Bhatnagar, M. Troggio, D. Pruss, ..., J. A. Fawcett, S. Proost, P. Rouze, L. Sterck, S. Toppo, B. Lazzari, R. P. Hellens, C. E. Durel, A. Gutin, R. E. Bumgarner, S. E. Gardiner, M. Skolnick, M. Egholm, Y. Van de Peer, F. Salamini, and R. Viola

The flowering world: a tale of duplications

2009

Trends in Plant Science

Y. Van de Peer, J. A. Fawcett, S. Proost, L. Sterck, and K. Vandepoele

PLAZA: a comparative genomics resource to study gene and genome evolution in plants

2009

The Plant Cell

S. Proost*, M. Van Bel*, L. Sterck, K. Billiau, T. Van Parys, Y. Van de Peer, and K. Vandepoele

Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression

2009

BMC Genomics

S. De Bodt, S. Proost, K. Vandepoele, P. Rouze, and Y. Van de Peer

* These authors contributed equally.