Sebastian Proost, PhD

Sebastian Proost, PhD

Bioinformatics | Data Science




Python12 years 
Data Science9 years 
Flask6 years 
HTML & CSS12 years 
Linux12 years 
JavaScript5 years 
R6 years 
1 patent, 39 publications, 7128 citations. H-index : 28
* These authors contributed equally to this work

Means and methods to diagnose gut flora dysbiosis and inflammation. Patent: WO2022073973A1 (2022)

J. Raes, S. Proost, G. Falony, S. Vieira-Silva, N. J. Timpson, D. A. Hughes

Google Patents

Long-term life history predicts current gut microbiome in a population-based cohort study. Nature Aging (2022)

J. Si, J. F. Vázquez-Castellanos, A. C. Gregory, L. Decommer, L. Rymenans, S. Proost, J. Centelles Lodeiro, M. Weger, M. Notdurfter, C. Leitner, P. Santer, G. Rungger, J. Willeit, P. Willeit, R. Pechlaner, F. Grabherr, S. Kiechl, H. Tilg and J. Raes

Nature Aging

High-energy level metabolism and transport revealed at the transition from close to open flowers. Plant Physiology (2022)

M. Borghi, L. Perez de Souza, T. Tohge, J. Mi, G. Melandri, S. Proost, M. Martins, S. Al-Babili, H. Bouwmeester and A. Fernie

Plant Physiology

The effect of ß-glucan prebiotic on kidney function, uremic toxins and gut microbiome in stage 3 to 5 chronic kidney disease (CKD) predialysis participants: a randomized controlled trial. Nutrients (2022)

Z. Ebrahim*, S. Proost*, R. Y. Tito, J. Raes, G. Glorieux, M. R. Moosa and R. Blaauw


The effect of oral iron supplementation on the gut microbiota, gut inflammation, and iron status in iron-depleted South African school-age children with virally suppressed HIV and without HIV. European Journal of Nutrition (2022)

C. Goosen*, S. Proost*, R. Y. Tito, J. Baumgartner, S. L. Barnabas, M. F. Cotton, M. B. Zimmermann, J. Raes and R. Blaauw

Springer Link

Topology of the redox network during induction of photosynthesis as revealed by time-resolved proteomics in tobacco. Science Advances (2021)

D. Zimmer, C. Swart, A. Graf, S. Arrivault, M. Tillich, S. Proost, Z. Nikoloski, M. Stitt, R. Bock, T. Mühlhaus and A. Boulouis

Science Advances

Comparative transcriptomic analysis reveals conserved transcriptional programs underpinning organogenesis and reproduction in land plants. Nature Plants (2021)

I. Julca, C. Ferrari, M. Flores-Tornero, S. Proost, A.-C. Lindner, ... , J. D. Becker and M. Mutwil


Kingdom-wide analysis of the evolution of the plant type III polyketide synthase superfamily. Plant Physiology (2021)

T. Naake, H. A. Maeda, S. Proost, T. Takayuki, A. R. Fernie


Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature (2020)

S. Vieira-Silva, G. Falony, E. Belda, T. Nielsen, J. Aron-Wisnewsky, R. Chakaroun, S. K. Forslund, K. Assmann, M. Valles-Colomer, T. T. D. Nguyen, S. Proost, ... , K. Clément and J. Raes


A novel seed plants gene regulates oxidative stress tolerance in Arabidopsis thaliana. Cellular and Molecular Life Sciences (2019)

N. Sujeeth, N. Mehterov, S. Gupta, M. K. Qureshi, A. Fischer, S. Proost, M. A. Omidbakhshfard, T. Obata, M. Benina, N. Staykov, S. Balazadeh, D. Walther, A. R. Fernie, B. Mueller-Roeber, J. Hille, T. S. Gechev


Appropriate thiamin pyrophosphate levels are required for acclimation to changes in photoperiod. Plant Physiology (2019)

L. Rosado-Souza, S. Proost, M. Moulin, S. Bergmann, S. Bocobza, A. Aharoni, T. B. Fitzpatrick, M. Mutwil, A. R. Fernie, T. Obata


Kingdom-wide comparison reveals the evolution of diurnal gene expression in Archaeplastida. Nature Communications (2019)

C. Ferrari, S. Proost, M. Janowski, J. Becker, Z. Nikoloski, D. Bhattacharya, D. Price, T. Tohge, A. Bar-Even, A. Fernie, M. Stitt, M. Mutwil


Transcriptomics of manually isolated Amborella trichopoda egg apparatus cells. Plant Reproduction (2019)

M. Flores-Tornero, S. Proost, M. Mutwil, C. P. Scutt, T. Dresselhaus, S. Sprunck


Multi‐tissue integration of transcriptomic and specialized metabolite profiling provides tools for assessing the common bean (Phaseolus vulgaris) metabolome. The Plant Journal (2018)

L. Perez de Souza, F. Scossa, S. Proost, E. Bitocchi, R Papa, T. Tohge, A. R. Fernie


CoNekT: an open-source framework for comparative genomic and transcriptomic network analyses. Nucleic Acids Research (2018)

S. Proost, M. Mutwil


PhytoNet: Comparative co-expression network analyses across phytoplankton and land plants. Nucleic Acids Research (2018)

C. Ferrari, S. Proost, C. Ruprecht, M. Mutwil


AtRsgA from Arabidopsis thaliana controls maturation of the small subunit of the chloroplast ribosome. The Plant Journal (2018)

M. Janowski, R. Zoschke, L Scharff, S. Martinez Jaime, C. Ferrari, S. Proost, N. Omranian, M. Musialak-Lange, Z. Nikoloski, A. Graf, M. A. Schottler, A. Sampathkumar, N. Vaid, M. Mutwil


LSTrAP: efficiently combining RNA sequencing data into co-expression networks. BMC Bioinformatics (2017)

S. Proost, A. Krawczyk, M. Mutwil


Expression atlas and comparative co-expression network analyses reveal important genes involved in the formation of lignified cell wall in Brachypodium distachyon. New Phytologist (2017)

R. Sibout, S. Proost, B. Hansen, N. Vaid, F. Giorgi, S. Ho-Yue-Kuang, F. Legée, L. Cezart, O. Bouchabké-Coussa, C. Soulhat, N. Provart, A. Pasha, P. Le Bris, E. Jamet, D. Roujol, H. Hoefte, C. Lapierre, S. Persson, M. Mutwil


Phylogenomic analysis of gene co-expression networks reveals evolution of functional modules. The Plant Journal (2017)

C. Ruprecht, S. Proost, M. Hernandez-Coronado, C. Ortiz-Ramirez, D. Lang, S. A. Rensing, J. D. Becker, K. Vandepoele, M. Mutwil


Beyond genomics: studying evolution with gene networks. Trends in Plant Science (2017)

C. Ruprecht, N. Vaid, S. Proost, S. Persson, M. Mutwil


PlaNet: Comparative Co-Expression Network Analyses for Plants. Plant Genomics Databases (Book Chapter) (2017)

S. Proost, M.Mutwil


Novel allelic variants in ACD6 cause hybrid necrosis in local collection of Arabidopsis thaliana. New Phytologist (2017)

M. Swiadek*, S. Proost*, D. Sieh, J. Yu, M. Todesco, C. Jorzig, A. E. Rodriguez Cubillos, B. Ploetner, Z. Nikoloski, E. Chae, P. Giavalisco, A. Fischer, F. Schroeder, S.-T. Kim, D. Weigel, R.A.E. Laitinen


Tools of the trade: studying molecular networks in plants. Current Opinion in Plant Biology (2016)

S. Proost, M.Mutwil


Growth-regulating factors (GRFs): a small transcription factor family with important functions in plant biology. Molecular Plant (2015)

M. A. Omidbakhshfard, S. Proost, U. Fujikura, B. Mueller-Roeber


The genome sequence of the orchid Phalaenopsis equestris. Nature Genetics (2015)

J. Cai*, X. Liu*, K. Vanneste*, S. Proost*, W.-C. Tsai*, K.-W. Liu*, ..., Y. Van de Peer, and Z.-J. Liu


PLAZA 3.0: an access point for plant comparative genomics. Nucleic Acids Research (2014)

S. Proost*, M. Van Bel*, D. Vaneechoutte, Y. Van de Peer, D. Inzé, B. Mueller-Roeber, and K. Vandepoele


Reversal of senescence by N resupply to N-starved Arabidopsis thaliana: transcriptomic and metabolomic consequences. Journal of Experimental Botany (2014)

S. Balazadeh, J. Schildhauer, W. L. Araújo, S. Munné-Bosch, A. R Fernie, S. Proost, K. Humbeck, and B. Mueller-Roeber


TRAPID: an efficient online tool for the functional and comparative analysis of de novo RNA-Seq transcriptomes. Genome Biology (2013)

M. Van Bel, S. Proost, C. Van Neste, D. Deforce, Y. Van de Peer, and K. Vandepoele


FLOWERING LOCUS C in monocots and the tandem origin of angiosperm-specific MADS-box genes. Nature Communications (2013)

P. Ruelens, R. A. de Maagd, S. Proost, G. Theißen, K. Geuten, and K. Kaufmann


Gamma paleohexaploidy in the stem lineage of core eudicots: significance for MADS-Box gene and species diversification. Molecular Biology and Evolution (2012)

D. Vekemans*, S. Proost*, K. Vanneste, H. Coenen, T. Viaene, P. Ruelens, S. Maere, Y. Van de Peer, and K. Geuten


Dissecting plant genomes with the PLAZA comparative genomics platform. Plant Physiology (2012)

M. Van Bel*, S. Proost*, E. Wischnitzki, S. Mohavedi, C. Scheerlinck, Y. Van de Peer, and K. Vandepoele


i-ADHoRe 3.0 - fast and sensitive detection of genomic homology in extremely large data sets. Nucleic Acids Research (2012)

S. Proost*, J. Fostier*, D. De Witte, B. Dhoedt, P. Demeester, Y. Van de Peer, and K. Vandepoele


The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011)

N. D. Young, F. Debelle, G. Oldroyd, R. Geurts, S. B. Cannon, M. K. Udvardi, V. A. Benedito, K. F. X. Mayer, J. Gouzy, H. Schoof, Y. Van de Peer, S. Proost, D. R. Cook, ..., D. C. Schwartz, J. Rogers, F. Quetier, C. D. Town, and B. A. Roe


Journey through the past: 150 million years of plant genome evolution. The Plant Journal (2011)

S. Proost, P. Pattyn, T. Gerats, and Y. Van de Peer


A greedy, graph-based algorithm for the alignment of multiple homologous gene lists. Bioinformatics (2011)

J. Fostier*, S. Proost*, B. Dhoedt, Y. Saeys, P. Demeester, Y. Van de Peer, and K. Vandepoele


The genome of the domesticated apple (Malus x domestica Borkh.). Nature genetics (2010)

R. Velasco, A. Zharkikh, J. Affourtit, A. Dhingra, A. Cestaro, A. Kalyanaraman, P. Fontana, S. K. Bhatnagar, M. Troggio, D. Pruss, ..., J. A. Fawcett, S. Proost, P. Rouze, L. Sterck, S. Toppo, B. Lazzari, R. P. Hellens, C. E. Durel, A. Gutin, R. E. Bumgarner, S. E. Gardiner, M. Skolnick, M. Egholm, Y. Van de Peer, F. Salamini, and R. Viola


The flowering world: a tale of duplications. Trends in Plant Science (2009)

Y. Van de Peer, J. A. Fawcett, S. Proost, L. Sterck, and K. Vandepoele


PLAZA: a comparative genomics resource to study gene and genome evolution in plants. The Plant Cell (2009)

S. Proost*, M. Van Bel*, L. Sterck, K. Billiau, T. Van Parys, Y. Van de Peer, and K. Vandepoele


Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression. BMC Genomics (2009)

S. De Bodt, S. Proost, K. Vandepoele, P. Rouze, and Y. Van de Peer