Sebastian Proost, PhD

Sebastian Proost, PhD

Bioinformatics | Data Science

sebastian.proost@gmail.com

Languages

DutchEnglishGermanFrench

Skills

Python15 years 
Data Science12 years 
Flask6 years 
HTML & CSS12 years 
Linux12 years 
R9 years 
JavaScript5 years 

Currently a Senior Postdoctoral Researcher at the VIB-KULeuven Center for Microbiology (Leuven, Belgium), focussing on the human gut microbiome and its connections to host health.

After earning a Masters degree in Biotechnology (UGent, Belgium), I pursued a PhD in Bioinformatics (VIB-UGent Center for Plant Systems Biology) combining my passion for life sciences with expertise in computer engineering.

Throughout my postdoctoral career, including time at the Max Planck Institute of Molecular Plant Physiology, I have increasingly specialized in software development and statistical analysis. This includes building web platforms for exploring large datasets and applying data science and machine learning techniques to deepen insights.

Full bio available under experience & education.

The common theme throughout my research is leveraging large datasets to tackle biological questions. This goes hand in hand with using modern (web) technology to create intuitive tools which allows domain experts to explore these data. Over the years I've been involved in the development of various platforms to study genome evolution, gene function, and microbial ecosystems. These have been used in a number of projects e.g. the Apple genome project, the Flemish Gut Flora Project, ... A full list of tools is avialable under software.

More details what I've been working on recently? Check out the media and publications pages!

Less serious topics I work on, outside of work (for fun or to hone my programmings skills), can be found on my blog 4DCu.be.

1 patent, 42 publications, 8430 citations. H-index : 30

Means and methods to diagnose gut flora dysbiosis and inflammation. Patent: WO2022073973A1 (2022)

J. Raes, S. Proost, G. Falony, S. Vieira-Silva, N. J. Timpson, D. A. Hughes

Google PatentsFPO

Beyond the Norm: epidemiology of irritable bowel syndrome and mental health among sexual and gender-diverse young adults in a large representative cohort. Gastroenterology (2024)

E. Bootsma*, L. Jansen*, K. van Houte, R. C. Kessler, J. Tack , R. Bruffaerts, Gut-Brain Interactions – WHO – World Mental Health International College Student Initiative Working Group [W. Voorspoels, S. Proost, P. Mortier, G. Kiekens, J. Alonso, J. Raes, G. Falony, S. Vieira-Silva, L. van Oudenhove, P. Cuijpers, R. P. Auerbach]

Gastroenterology

Mood disorders in higher education in Flanders during the 2nd COVID-19 wave: Prevalence and help-seeking: Findings from the Flemish College Surveys (FLeCS). Journal of Psychiatric Research (2023)

E. Bootsma*, L. Jansen*, G. Kiekens, W. Voorpoels, P. Mortier, S. Proost, I. van de Poel, K. Jacobs, K. Demyttenaere, J. Alonso, R. C. Kessler, P. Cuijpers, R. P. Auerbach and R. Bruffaerts

Journal of Psychiatric Research

Long-term life history predicts current gut microbiome in a population-based cohort study. Nature Aging (2022)

J. Si, J. F. Vázquez-Castellanos, A. C. Gregory, L. Decommer, L. Rymenans, S. Proost, J. Centelles Lodeiro, M. Weger, M. Notdurfter, C. Leitner, P. Santer, G. Rungger, J. Willeit, P. Willeit, R. Pechlaner, F. Grabherr, S. Kiechl, H. Tilg and J. Raes

Nature Aging

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis. Nature (2020)

S. Vieira-Silva, G. Falony, E. Belda, T. Nielsen, J. Aron-Wisnewsky, R. Chakaroun, S. K. Forslund, K. Assmann, M. Valles-Colomer, T. T. D. Nguyen, S. Proost, ... , K. Clément and J. Raes

PubMed

CoNekT: an open-source framework for comparative genomic and transcriptomic network analyses. Nucleic Acids Research (2018)

S. Proost, M. Mutwil

PubMedGitHub